The Lilywhites beat Burnley 1-0 in the previous round, while City thrashed Huddersfield Town 5-0 to make it thus far in the competition.
Tottenham don’t have any European football this season while they have already been eliminated from the EFL Cup, so the FA Cup represents their best chance for silverware.
Ange Postecoglou’s style of play has been a massive hit with the Spurs’ supporters, but he will now be bidding to end their long trophy drought.
The Lilywhites defeated Burnley 1-0 in the third-round, thanks to an outrageous second-half strike from Pedro Porro.
It was far from a vintage performance from the North Londoners, but they managed to win and that’s what mattered in the end.
Ange Postecoglou’s men then met Manchester United in the Premier League, with the two sides playing out a thrilling 2-2 draw at Old Trafford.
The hosts twice took the lead through Rasmus Hojlund and Marcus Rashford but were pegged back each time by Richarlison and Rodrigo Bentancur, with the game eventually ending in a stalemate.
Tottenham now face Manchester City who seem to have fully hit their stride.
The Citizens destroyed Huddersfield Town 5-0 at the Etihad Stadium, with four of their players earning their names on the scoresheet.
Pep Guardiola’s side followed that up with a 3-2 success over Newcastle United earlier this January.
The Magpies were leading 2-1 at the break but Kevin de Bruyne’s introduction in the second-half completely changed the game.
The returning hero found the bottom corner with a low finish before setting up 20-year-old Oscar Bobb for City’s late winner.
Tottenham will continue to be without Son Heung-min, Pape Matar Sarr, and Yves Bissouma due to their international commitments. Meanwhile, Alejo Veliz, Ben Davies, Giovani Lo Celso and Dane Scarlett also remain unavailable because of their injury issues.
As for Manchester City, Ederson, John Stones and Manuel Akanji will be missing on Friday due to their fitness problems. However, in a big boost, Erling Haaland is expected to make it to the matchday squad after recovering from his foot injury.
Tottenham Hotspur vs Manchester City potential line-ups
Tottenham Hotspur: Vicario; Porro, Romero, Van de Ven, Udogie; Hojbjerg, Bentancur; Johnson, Kulusevski, Werner; Richarlison
Manchester City: Ortega; Walker, Dias, Ake, Gvardiol; Rodri, Kovacic; Silva, De Bruyne, Foden; Alvarez
How to Watch?
Enjoy all FA Cup live matches, including the upcoming Tottenham vs Manchester City fixture.
Tottenham Hotspur vs Manchester City prediction
Manchester City have lost all their previous five meetings with Spurs at the Tottenham Hotspur Stadium without scoring a single goal. Will their miserable run at the venue continue this weekend? We don’t think so, as Pep Guardiola’s side have seemingly hit their stride recently. They have also received a boost with the return of Kevin de Bruyne.
Tottenham Hotspur 1-2 Manchester City
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